Hepatitis E

Viral Diseases

Animals Involved

People; animals, including swine, wild boar, deer, rabbits, ferrets, rats, mongoose, others; swine and probably other hosts are reservoirs for human infections

Known Distributions

Worldwide; human and zoonotic genotypes may differ in prevalence between areas

Probable Means of Spreading

Fecal­oral spread; consumption of raw or undercooked meat and liver; waterborne, contact with animal reservoirs

Clinical Manifestations in People

Mild, self­limiting hepatitis to liver failure, more severe in pregnancy and can result in abortion, death of newborn, premature birth; usually acute, but can be chronic in organ­ transplant patients; case fatality rate <1% to 4% in general population, up to 20% in pregnant

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