Animals Involved
Deer are probably major reservoir in North America, dogs and other canids, lemurs, other mammals can also be infected
Known Distributions
North America; also reported in South America, Asia, and Africa
Probable Means of Spreading
Ticks, including Amblyomma americanum
Clinical Manifestations in People
Asymptomatic to nonspecific febrile illness; rash in many pediatric cases, some adults; may progress to prolonged fever, renal failure, respiratory distress, hemorrhages,
cardiomyopathy, neurologic signs, multiorgan failure; more severe in immunosuppressed, elderly; estimated case fatality rate 2%–3%